Discordant erythropoiesis in CML
نویسندگان
چکیده
منابع مشابه
MicroRNA-486 regulates normal erythropoiesis and enhances growth and modulates drug response in CML progenitors.
MicroRNAs (miRNAs) are key regulators of hematopoietic cell differentiation and may contribute to altered growth of leukemic stem cells. Using microarray-based miRNA profiling, we found that miRNA 486 (miR-486) is significantly upregulated in chronic myeloid leukemia (CML) compared with normal CD34(+) cells, particularly in the megakaryocyte-erythroid progenitor population. miR-486-5p expressio...
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study of an anti-CD30 monoclonal antibody (MDX-060) in Hodgkin's lymphoma and anaplastic large-cell lymphoma. Leen AM, et al. Complete responses of relapsed lymphoma following genetic modification of tumor-antigen presenting cells and T-lymphocyte transfer. Predicting response in chronic myeloid leukemia (CML) patients who are offered tyrosine kinase inhibitor (TKI) second-line therapy is vital...
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Among the hematologic malignancies, the genetic lesion in chronic myelogenous leukemia (CML) resulting in Bcr-Abl tyrosine kinase has become a hallmark target for therapeutic intervention. Inhibition of Bcr-Abl tyrosine kinase is a poster child for kinasetargeted therapeutics. Unlike CML, chronic lymphocytic leukemia (CLL) does not have a genetic lesion associated with pathophysiology or biolog...
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Current techniques to concurrent map building and localization (CML) have been devised for static environments, and lack robustness in more realistic situations. In this communication we provide new ideas that extend the typical stochastic estimation approach to CML, to take into account the dynamics of the environment. The basic idea consists on using the history of data association mismatches...
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By WENDELL F. RossE, THOMAS WALDMANN AND ELEANOR Huu. H YPOXIA AND ANEMIA have been known for many years to stimulate erythropoiesis in mammals, including man.1 In recent years, these stimuli have been shown to have their effect through a humoral factor, erythropoietin.2 J acobson, et al. have suggested that lack of oxygen, relative to the metabolic needs of the animal, is the fundamental stimu...
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ژورنال
عنوان ژورنال: Leukemia
سال: 1998
ISSN: 0887-6924,1476-5551
DOI: 10.1038/sj.leu.2400955